Center of Experimental Morphology

Departamento de Anatomia - Faculdade de Medicina da Universidade do Porto

[ Back ]

Multiple Sclerosis Severity Score: Using disability and disease duration to rate disease severity


Research Area: Uncategorized Year: 2005
Type of Publication: Article
Authors:
  • Sá, M. J.
  • Roxburgh, R.
  • Seaman, S. R.
  • Masterman, T.
  • Silva, A. M.
  • Marta, M.
  • Leite, I.
  • Dubois, B.
Journal: Neurology Volume: 64
Pages: 1144-1151
BibTex:
Abstract:
Background: There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease. Methods: Using data from two large longitudinal databases, the authors tested whether cross-sectional disability assessments are representative of disease severity as a whole. An algorithm, the Multiple Sclerosis Severity Score (MSSS), which relates scores on the Expanded Disability Status Scale (EDSS) to the distribution of disability in patients with comparable disease durations, was devised and then applied to a collection of 9,892 patients from 11 countries to create the Global MSSS. In order to compare different methods of detecting such effects the authors simulated the effects of a genetic factor on disability. Results: Cross-sectional EDSS measurements made after the first year were representative of overall disease severity. The MSSS was more powerful than the other methods the authors tested for detecting different rates of disease progression. Conclusion: The Multiple Sclerosis Severity Score (MSSS) is a powerful method for comparing disease progression using single assessment data. The Global MSSS can be used as a reference table for future disability comparisons. While useful for comparing groups of patients, disease fluctuation precludes its use as a predictor of future disability in an individual.

Contactos
Centro de Morfologia Experimental
Faculdade de Medicina da Universidade do Porto
Al. Professor Hernâni Monteiro
4200-319 Porto
tel. (+351) 22 551 36 16
fax (+351) 22 551 36 17
correio This e-mail address is being protected from spambots. You need JavaScript enabled to view it
© 2017 Departamento de Anatomia / Produção CI FMUP