Center of Experimental Morphology

Departamento de Anatomia - Faculdade de Medicina da Universidade do Porto

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Sexually dimorphic response of the hypothalamo–pituitary–adrenal axis to chronic alcohol consumption and withdrawal

Research Area: Uncategorized Year: 2009
Type of Publication: Article Keywords: Alcohol,Withdrawal,Hypothalamo pituitary adrenal axisnext term,Gonadal steroids
Journal: Brain Research Volume: 1303
Number: 25 Pages: 61-73
Month: November
In males, long-term previous termalcohol consumptionnext term provokes neurochemical changes in the medial parvocellular division of the PVN (PVNmp) that are partially reversed by previous term Because gonadal steroids modulate the activity of the previous termhypothalamo–pituitary–adrenal axis,next term we analyzed the possibility that the repercussions of previous termchronic alcohol consumption and withdrawalnext term on the anatomy and neurochemistry of the PVNmp might differ between the sexes. Male and female Wistar rats were examined after ingesting a 20% previous termalcoholnext term solution for 6 months or after 2 months of previous termwithdrawalnext term from 6 months of previous termalcohol term The levels of gonadal steroids and the basal concentrations of corticosterone were also evaluated. previous termChronic alcohol consumption and withdrawalnext term did not alter the global cytoarchitectonic features of the PVNmp in rats of both sexes. However, previous termalcohol consumptionnext term was associated with a decrease in the number of vasopressin (VP) neurons only in females and of corticotropin releasing hormone (CRH) neurons in males and females. Further, the previous termresponse to withdrawal was sexually dimorphicnext term because in males there was a partial recovery of the number of CRH neurons whereas in females there was a further loss of VP and CRH neurons. Corticosterone levels were unchanged by previous termalcohol consumption,next term but they were decreased by previous termwithdrawalnext term in females. previous termAlcohol consumption and withdrawalnext term did not alter estrogen and progesterone concentrations in females, but decreased testosterone levels in males. These findings show that the previous termresponsenext term of CRH and VP neurons to excess previous termalcoholnext term is gender-specific, with females being more vulnerable during previous termalcohol consumptionnext term and, most notably, after previous term

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