Center of Experimental Morphology

Departamento de Anatomia - Faculdade de Medicina da Universidade do Porto

Paula-Barbosa, Manuel M., MD, PhD

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Paula-Barbosa, Manuel M.
Personal Information

Retired Professor


Academic degrees

Graduated from The Faculty of Medicine, University of Porto, 1970.
Ph.D. Faculty of Medicine, University of Porto, 1977.
Habilitation, Faculty of Medicine, University of Porto, 1982.

Positions Held

1970-1973 Assistant, Faculty of Medicine, University of Porto
1973-1974 Invited Researcher University College London
1974-1977 Assistant, Faculty of Medicine, University of Porto
1977-1979 Assistant Professor, Faculty of Medicine, University of Porto
1979-1984 Associate Professor, Faculty of Medicine, University of Porto
1984- Full Professor, Faculty of Medicine, University of Porto
1994- Director of The Institute of Anatomy, Faculty of Medicine, University of Porto
1994-2005 Scientific Coordinator, Center of Experimental Morphology, FCT

Research Interests

Cellular and System Neuroscience, Neurotrophins and Neuropeptides, Limbic System, Effects of Alcohol in the Brain.

Publications

  • Pereira, P., Santos, D., Neves, J., Madeira, M. D. & Paula-Barbosa, M. M. (2013). Nerve growth factor retrieves neuropeptide Y and cholinergic immunoreactivity in the nucleus accumbens of old rats. Neurobiol Aging.(34(8), 1988-95. [More] 
  • Sá, S. I., Pereira, P. A., Paula-Barbosa, M. M. & Madeira, M. D. (2010). Role of neural afferents as mediators of estrogen effects on the hypothalamic ventromedial nucleus. Brain Research(1366), 60-70. [More] 
  • Cardoso, A., Madeira, M. D., Paula-Barbosa, M. M. & Lukoyanov, N. (2008). Retrosplenial granular b cortex in normal and epileptic rats: A stereological study. Brain Research, 1218, 206-214. [More] 
  • Carneiro, Â., Assunção, M., de Freitas, V., Paula-Barbosa, M. M. & Andrade, J. P. (2008). Red Wine, but not Port Wine, Protects Rat Hippocampal Dentate Gyrus Against Ethanol-Induced Neuronal Damage—Relevance of the Sugar Content. Alcohol & Alcoholism, 43(4), 408-415. [More] 
  • Cardoso, A., Assunção, M., Andrade, J. P., Pereira, P. A., Madeira, M. D., Paula-Barbosa, M. M. et al. (2008). Loss of Synapses in the Entorhinal-Dentate Gyrus Pathway FollowingRepeated Induction of Electroshock Seizures in the Rat. Journal of Neuroscience Research(86), 71-83. [More] 
  • Assunção, M., , ., de Freitas, V., Paula-Barbosa, M. M. & Carvalho, F. (2008). Modulation of rat cerebellum oxidative status by prolonged red wine consumption. Addiction Biology(13), 337-344. [More] 
  • Cardoso, A., Assunção, M., Andrade, J. P., Pereira, P. A., Madeira, M. D., Paula-Barbosa, M. M. et al. (2007). Loss of Synapses in the Entorhinal-Dentate Gyrus Pathway FollowingRepeated Induction of Electroshock Seizures in the Rat. Journal of Neuroscience Research(86), 71-83. [More] 
  • Assunção, M., , ., de Freitas, V., Carvalho, F., Andrade, J. P., Lukoyanov, N. et al. (2007). Red Wine Antioxidants Protect Hippocampal Neurons Against Ethanol-Induced Damage: A Biochemical, Morphological And Behavioral Study. Brain Research(146), 1581-1592. [More] 
  • Assunção, M., de Freitas, V. & Paula-Barbosa, M. M. (2007). Grape seed flavanols, but not Port wine, prevent ethanol-induced neuronal lipofuscin formation. Brain Research(1129), 72-80. [More] 
  • Cardoso, A., Paula-Barbosa, M. M. & Lukoyanov, N. (2006). Reduced density of neuropeptide Y neurons in the somatosensory cortex of old male and female rats: relation to cholinergic depletion and recovery after nerve growth factor treatment. Neuroscience, 137(3), 937-948. [More] 
  • Pereira, P. A., Cardoso, A. & Paula-Barbosa, M. M. (2005). Nerve growth factor restores the expression of vasopressin and vasoactive intestinal polypeptide in the suprachiasmatic nucleus of aged rats.. Brain Research, 1048(1-2), 123-130. [More] 
  • Lukoyanov, N., , ., Andrade, J. P. & Paula-Barbosa, M. M. (2005). Impaired water maze navigation of Wistar rats with retrosplenialnext term cortex lesions: effect of nonspatial pretraining. Behavioural Brain Research, 158(1), 175-182. [More] 
  • Paula-Barbosa, M. M., Pereira, P. A., Cardoso, A., Madeira, M. D. & Cadete-Leite, A. (2004). The effects of nerve growth factor upon the neuropeptide content of the suprachiasmatic nucleus of rats withdrawn from ethanol are mediated by the nucleus basalis magnocellularis. Journal of Neurocytology, 33, 453-463. [More] 
  • Sá, M. J., Madeira, M. D., Ruela, C., Volk, B., Mota Miranda, A. & Paula-Barbosa, M. M. (2004). Dendritic changes in the hippocampal formation of AIDS patients a quantitative Golgi study. Acta Neuropathol, 107, 97-110. [More] 
  • Madeira, M. D., Pereira, P. A., Ferreira, S. M., Cadete-Leite, A. & Paula-Barbosa, M. M. (2004). Basal forebrain neurons modulate the synthesis and expression of neuropeptidesnext term in the rat suprachiasmatic nucleus. Neuroscience, 125(4), 889-901. [More] 
  • Freitas, V., Silva, P., Assunção, M., Cadete-Leite, A., Andrade, J. P. & Paula-Barbosa, M. M. (2004). Flavonoids from grape seeds prevent the increased alcohol-induced neuronal lipofuscin formation.. Alcohol & Alcoholism, 30(4), 303-311. [More] 
  • Lukoyanov, N., Sá, M. J., Madeira, M. D. & Paula-Barbosa, M. M. (2003). Selective loss of hilar neurons and impairment of initial learning in rats after repeated administration of electroconvulsive shock seizures. Experimental Brain Research, 154, 192-200. [More] 
  • Paula-Barbosa, M. M., Pereira, P. A., Cadete-Leite, A. & Madeira, M. D. (2003). NGF and NT-3 exert differential effects on the expression of neuropeptides in the suprachiasmatic nucleus of rats withdrawn from ethanol treatment. Brain Research, 983(1-2), 64-73. [More] 
  • Cadete-Leite, A., Pereira, P. A., Madeira, M. D. & Paula-Barbosa, M. M. (2003). Nerve growth factor prevents cell death and induces hypertrophy of basal forebrain cholinergic neurons in rats withdrawn from prolonged ethanol intake. Neuroscience, 119(4), 1055-1069. [More] 
  • Cash, A. D., Aliev, G., Paula-Barbosa, M. M., Nunomura, A., Avíla, J., Fujioka, H. et al. (2003). Microtubule reduction in Alzheimer’s disease and aging is independent of filament formation. The American Journal of Pathology, 162(5), 1623-1627. [More] 
  • Lukoyanov, N., Pereira, P. A., Paula-Barbosa, M. M. & Cadete-Leite, A. (2003). Nerve growth factor improves spatial learning and restores hippocampal cholinergic fibers in rats withdrawn from chronic treatment with ethanol. Experimental Brain Research, 148(1), 88-94. [More] 
  • Ferreira, S. M., Paula-Barbosa, M. M. & Madeira, M. D. (2002). Prolonged alcohol intake leads to reversible depression of corticotropin-releasing hormone and vasopressin immunoreactivity and mRNA levels in the parvocellular neurons of the paraventricular nucleus.. Brain Research, 954(1), 82-93. [More] 
  • Ferreira, S. M., Madeira, M. D., Ruela, C. & Paula-Barbosa, M. M. (2002). Prolonged alcohol intake leads to irreversible loss of vasopressin and oxytocin neurons in the paraventricular nucleus of the hypothalamus. Brain Research, 925(1), 76-88. [More] 
  • Andrade, J. P., Lukoyanov, N. & Paula-Barbosa, M. M. (2002). Chronic Food Restriction Is Associated With Subtle Dendritic Alterations in Granule Cells of the Rat Hippocampal Formation. Hippocampus, 12(2), 149-164. [More] 
  • Madeira, M. D., Ferreira-Silva, L., Ruela, C. & Paula-Barbosa, M. M. (2001). Differential effects of the aging process on the morphology of the hypothalamic ventromedial nucleus of male and female rats.. Neuroscience Letters, 314(1-2), 73-76. [More] 
  • Lukoyanov, N. & Paula-Barbosa, M. M. (2001). Memantine, but not dizocilpine, ameliorates cognitive deficits in adult rats withdrawn from chronic ingestion of alcohol.. Neuroscience Letters, 309(1), 45-48. [More] 
  • Madeira, M. D., Silva, L. F. & Paula-Barbosa, M. M. (2001). Influence of sex and estrus cycle on the sexual dimorphisms of the hypothalamic ventromedial nucleus: stereological and Golgi study.. Journal of Comparative Neurology, 432(3), 329-345. [More] 
  • Paula-Barbosa, M. M., Ferreira, S. M., Andrade, J. P., Cadete-Leite, A. & Madeira, M. D. (2001). Nerve growth factor restores mRNA levels and the expression of neuropeptides in the suprachiasmatic nucleus of rats submitted to chronic ethanol treatment and withdrawal.. Journal of Neurocytology, 30(3), 195-207. [More] 
  • Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (2000). Sexual dimorphism in the subiculum of the rat hippocampal formation. Brain Research, 875(1-2), 125-137. [More] 
  • Sá, M. J., Madeira, M. D., Ruela, C., Volk, B., Mota Miranda, A., Lecour, H. et al. (2000). AIDS does not alter the total number of neurons in the hippocampal formation but induces cell atrophy: a stereological study. Acta Neuropathologica, 99(6), 643-653. [More] 
  • Lukoyanov, N. & Paula-Barbosa, M. M. (2000). A single high dose of dizocilpine produces long-lasting impairment of the water maze performance in adult rats. Neuroscience Letters, 285(2), 139-142. [More] 
  • Sousa, N., Lukoyanov, N., Madeira, M. D., Almeida, F. X. & Paula-Barbosa, M. M. (2000). Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience, 97(2), 253-266. [More] 
  • Madeira, M. D., Andrade, J. P. & Paula-Barbosa, M. M. (2000). Hypertrophy of the ageing rat medial preoptic nucleus. Journal of Neurocytology, 29(3), 173-197. [More] 
  • Lukoyanov, N., Brandão, F., Cadete-Leite, A., Madeira, M. D. & Paula-Barbosa, M. M. (2000). Synaptic reorganization in the hippocampal formation of alcohol-fed rats may compensate for functional deficits related to neuronal loss. Alcohol, 20(2), 139-148. [More] 
  • Sousa, N., Madeira, M. D. & Paula-Barbosa, M. M. (1999). Corticosterone replacement restores normal morphological features to the hippocampal dendrites, axons and synapses of adrenalectomized rats. Journal of Neurocytology, 28(7), 541-558. [More] 
  • Lukoyanov, N., Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1999). Effects of age and sex on the water maze performance and hippocampal cholinergic fibers in rats. Neuroscience Letters, 269(3), 141-144. [More] 
  • Sousa, N., Paula-Barbosa, M. M. & Almeida, O. F. (1999). Ligand and subfield specificity of corticoid-induced neuronal loss in the rat hippocampal formation.. Neuroscience, 89(4), 1079-1087. [More] 
  • Lukoyanov, N., Madeira, M. D. & Paula-Barbosa, M. M. (1999). Behavioral and Neuroanatomical Consequences of Chronic Ethanol Intake and Withdrawal. Physiology & Behavior, 66(2), 337-346. [More] 
  • Madeira, M. D., Leal, S. & Paula-Barbosa, M. M. (1999). Stereological evaluation and Golgi study of the sexual dimorphisms in the volume, cell numbers, and cell size in the medial preoptic nucleus of the rat. Journal of Neurocytology, 28(2), 131-148. [More] 
  • Madeira, M. D. & Paula-Barbosa, M. M. (1999). Effects of alcohol on the synthesis and expression of hypothalamic peptides. Brain Research Bulletin, 48(1), 3-22. [More] 
  • Sá, M. J., Pereira, A., Paula-Barbosa, M. M. & Madeira, M. D. (1999). Anatomical asymmetries in the human hippocampal formation. Acta stereologica, 18(2), 161-176. [More] 
  • Sousa, N., Madeira, M. D. & Paula-Barbosa, M. M. (1998). Effects of corticosterone treatment and rehabilitation on the hippocampal formation of neonatal and adult rats. An unbiased stereological study. Brain Research, 794(2), 199-210. [More] 
  • Sousa, N., Almeida, O. F., Holsboer, F., Paula-Barbosa, M. M. & Madeira, M. D. (1998). Maintenance of hippocampal cell numbers in young and aged rats submitted to chronic unpredictable stress. Comparison with the effects of corticosterone treatment. Stress, 2(4), 237-249. [More] 
  • Leal, S., Andrade, J. P., Paula-Barbosa, M. M. & Madeira, M. D. (1998). Arcuate nucleus of the hypothalamus: Effects of age and sex. The Journal of Comparative Neurology, 401, 65-88. [More] 
  • Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1998). Differential vulnerability of the subiculum and entorhinal cortex of the adult rat to prolonged protein deprivation. Hippocampus, 8(1), 33-47. [More] 
  • Cadete-Leite, A., Brandão, F., Andrade, J. P., Ribeiro-da-Silva, A. & Paula-Barbosa, M. M. (1997). The GABAergic system of the dentate gyrus after withdrawal from chronic alcohol consumption. Effects of intracerebral grafting and putative neuroprotective agents. Alcohol and Alcoholism, 32(4), 471-484. [More] 
  • Sousa, N., Madeira, M. D. & Paula-Barbosa, M. M. (1997). Structural alterations of the hippocampal formation of adrenalectomizd rats: an unbiased stereological study. Journal of Neurocytology, 26(6), 423-438. [More] 
  • Madeira, M. D., Andrade, J. P., Lieberman, A. R., Paula-Barbosa, M. M., Sousa, N. & Almeida, O. F. (1997). Chronic Alcohol Consumption and Withdrawal Do Not Induce Cell Death in the Suprachiasmatic Nucleus, But Lead to Irreversible Depression of Peptide Immunoreactivity and mRNA Levels. The Journal of Neuroscience, 17(4), 1302-1319. [More] 
  • Madeira, M. D., Sousa, N. & Paula-Barbosa, M. M. (1996). Effects of high and low levels of glucocorticoids on the morphology of the hippocampal formation: A stereological study. Morphometry and its Applications in Medical Sciences, 227-240. [More] 
  • Brandão, F., Cadete-Leite, A., Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1996). Piracetam promotes mossy fiber synaptic reorganization in rats withdrawn from alcohol. Alcohol, 13(3), 239-249. [More] 
  • Andrade, J. P. & Paula-Barbosa, M. M. (1996). Protein malnutrition alters the cholinergic and GABAergic systems of the hippocampal formation of the adult rat: an immunocytochemical study. Neuroscience Letters, 211, 211-215. [More] 
  • Andrade, J. P., Castanheira-Vale, A. J., Paz-Dias, P. G., Madeira, M. D. & Paula-Barbosa, M. M. (1996). The dendritic trees of the neurons from the hippocampal formation of adult protein-deprived rats. A quantitative Golgi study. Experimental Brain Research, 109, 419-433. [More] 
  • Madeira, M. D., Sousa, N., Santer, R. M., Paula-Barbosa, M. M. & Gundersen, H. (1995). Age and sex do not affect the volume, cell numbers, or cell size of the suprachiasmatic nucleus of the rat: an unbiased stereological study.. Journal of Comparative Neurology, 361(4), 585-601. [More] 
  • Sá, M. J., Madeira, M. D., Cruz, C. & Paula-Barbosa, M. M. (1995). Morphometric study of the frontal cortex in subacute sclerosing panencephalitis. Acta Neurologica Scandinavica, 92(3), 225-230. [More] 
  • Sousa, N., Madeira, M. D., Ruela, C. & Paula-Barbosa, M. M. (1995). Structural reorganization in the supraoptic nucleus of withdrawn rats following long-term alcohol consumption. Alcoholism: Clinical and Experimental Research, 19(4), 879-885. [More] 
  • Brandão, F., Paula-Barbosa, M. M. & Cadete-Leite, A. (1995). Piracetam impedes hippo-campal neuronal loss during withdrawal after chronic alcohol intake. Alcohol, 12(3), 279-288. [More] 
  • Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1995). Evidence of reorganization in the hippocampal mossy fiber synapses of adult rats rehabilitated after prolonged undernutrition. Experimental Brain Research, 104, 249-261. [More] 
  • Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1995). Effects of long-term malnutrition and rehabilitation on the hippocampal formation of the adult rat. Journal of Anatomy, 187, 379-393. [More] 
  • Sousa, N., Madeira, M. D., Paula-Barbosa, M. M. & Bujis, R. (1994). The vasopressinergic innervation of the lateral septum of the rat after chronic alcohol consumption and withdrawal. Brain Research, 648(1), 53-58. [More] 
  • Ruela, C., Sousa, N., Madeira, M. D. & Paula-Barbosa, M. M. (1994). Stereological study of the ultrastructural changes induced by chronic alcohol consumption and dehydration in the supraoptic nucleus of the rat hypothalamus. Journal of Neurocytology, 23, 410-421. [More] 
Contactos
Centro de Morfologia Experimental
Faculdade de Medicina da Universidade do Porto
Al. Professor Hernâni Monteiro
4200-319 Porto
tel. (+351) 22 551 36 16
fax (+351) 22 551 36 17
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