Center of Experimental Morphology

Departamento de Anatomia - Faculdade de Medicina da Universidade do Porto

Madeira, Maria Dulce, MD, PhD

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Personal Information

Professor, Sci. Coordinator of CME

e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it | phone: (351) 225513616
Location: Porto


Academic degrees

1995 Habilitation (Morphology), Porto Medical School
1990 PhD (Morphology), Porto Medical School
1989 Master degree (Morphology), Porto Medical School
1978 MD degree, Porto Medical School

Present appointment

2001 Full Professor of Anatomy, Porto Medical School

Previous appointments

1992-2001 Associate Professor of Anatomy, Porto Medical School
1990-1992 Assistant Professor of Anatomy, Porto Medical School
1989-1990 Assistant of Anatomy, Porto Medical School
1988-1995 Hospital Assistant, Endocrinology, Hospital S. João, Porto
1983-1989 Invited Assistant of Anatomy, Porto Medical School
1983-1987 Endocrinology residency, Hospital S. João, Porto
1979-1983 General Internship, Hospital S. João, Porto
1977-1983 Tutor of Anatomy, Porto Medical School

Scientific interests

Neuroendocrinology. Neuronal plasticity. Sexual dimorphism. Aging. Hypothalamus. Limbic system.

Publications

  • Pereira, P. A., Neves, J., Vilela, M., Sousa, S., Cruz, C. & Madeira, M. D. (2014). Chronic alcohol consumption leads to neurochemical changes in the nucleus accumbens that are not fully reversed by withdrawal. Neurotoxicol Teratol(44), 53-61. [More] 
  • Sá, S. I., Pereira, P. A., Malikov, V., Ferreira, I. & Madeira, M. D. (2014). Role of plasma membrane estrogen receptors in mediating the estrogen induction of progesterone receptors in hypothalamic ventromedial neurons. Issue Journal of Comparative Neurology Journal of Comparative Neurology(522), 298-307. [More] 
  • Pereira, P., Santos, D., Neves, J., Madeira, M. D. & Paula-Barbosa, M. M. (2013). Nerve growth factor retrieves neuropeptide Y and cholinergic immunoreactivity in the nucleus accumbens of old rats. Neurobiol Aging.(34(8), 1988-95. [More] 
  • Sá, S. I., Pereira, P. A., Malikov, V. & Madeira, M. D. (2013). Role of estrogen receptor α and β in the induction of progesterone receptors in hypothalamic ventromedial neurons. Neuroscience(238), 159-67. [More] 
  • Sá, S. I. & Madeira, M. D. (2012). Sex Steroid Hormones Regulate the Expression of Growth-associated Protein 43, Microtubule-associated Protein 2, Synapsin 1 and Actin in the Ventromedial Nucleus of the Hypothalamus. J Mol Neurosci. [More] 
  • Cardoso, A., , ., Madeira, M. D. & Lukoyanov, N. (2011). Seizure-induced structural and functional changes in the rat hippocampal formation: Comparison between brief seizures and status epilepticus. Behavioural brain research(225), 538-546. [More] 
  • Sá, S. I., Pereira, P. A., Paula-Barbosa, M. M. & Madeira, M. D. (2010). Role of neural afferents as mediators of estrogen effects on the hypothalamic ventromedial nucleus. Brain Research(1366), 60-70. [More] 
  • Ferreira, S. M., , . & Madeira, M. D. (2009). Sexually dimorphic response of the hypothalamo–pituitary–adrenal axis to chronic alcohol consumption and withdrawal. Brain Research, 1303(25), 61-73. [More] 
  • , ., Madeira, M. D. & Sá, S. I. (2009). Effects of estrogens and progesterone on the synaptic organization of the hypothalamic ventromedial nucleus. Neuroscience(162), 307-316. [More] 
  • Cardoso, A., Madeira, M. D., Paula-Barbosa, M. M. & Lukoyanov, N. (2008). Retrosplenial granular b cortex in normal and epileptic rats: A stereological study. Brain Research, 1218, 206-214. [More] 
  • Cardoso, A., Assunção, M., Andrade, J. P., Pereira, P. A., Madeira, M. D., Paula-Barbosa, M. M. et al. (2008). Loss of Synapses in the Entorhinal-Dentate Gyrus Pathway FollowingRepeated Induction of Electroshock Seizures in the Rat. Journal of Neuroscience Research(86), 71-83. [More] 
  • Cardoso, A., Assunção, M., Andrade, J. P., Pereira, P. A., Madeira, M. D., Paula-Barbosa, M. M. et al. (2007). Loss of Synapses in the Entorhinal-Dentate Gyrus Pathway FollowingRepeated Induction of Electroshock Seizures in the Rat. Journal of Neuroscience Research(86), 71-83. [More] 
  • Sá, M. J., Ruela, C. & Madeira, M. D. (2007). Dendritic Right/Left Asymmetries in the Neurons of the Human Hippocampal Formation: A Quantative Study. Arquivos de Neuropsiquiatria, 4B(65), 1105-1113. [More] 
  • Sá, S. I. & Madeira, M. D. (2005). Neuronal organelles and nuclear pores of hypothalamicnext term ventromedial neurons are sexually dimorphic and change during the estrus cycle in the rat. Neuroscience, 133(4), 919-924. [More] 
  • Sá, S. I. & Madeira, M. D. (2005). Estrogen Modulates the Sexually Dimorphic Synaptic Connectivity of the Ventromedial Nucleus. The Journal of Comparative Neurology, 484, 68-79. [More] 
  • Paula-Barbosa, M. M., Pereira, P. A., Cardoso, A., Madeira, M. D. & Cadete-Leite, A. (2004). The effects of nerve growth factor upon the neuropeptide content of the suprachiasmatic nucleus of rats withdrawn from ethanol are mediated by the nucleus basalis magnocellularis. Journal of Neurocytology, 33, 453-463. [More] 
  • Sá, M. J., Madeira, M. D., Ruela, C., Volk, B., Mota Miranda, A. & Paula-Barbosa, M. M. (2004). Dendritic changes in the hippocampal formation of AIDS patients a quantitative Golgi study. Acta Neuropathol, 107, 97-110. [More] 
  • Madeira, M. D., Pereira, P. A., Ferreira, S. M., Cadete-Leite, A. & Paula-Barbosa, M. M. (2004). Basal forebrain neurons modulate the synthesis and expression of neuropeptidesnext term in the rat suprachiasmatic nucleus. Neuroscience, 125(4), 889-901. [More] 
  • Lukoyanov, N., Sá, M. J., Madeira, M. D. & Paula-Barbosa, M. M. (2003). Selective loss of hilar neurons and impairment of initial learning in rats after repeated administration of electroconvulsive shock seizures. Experimental Brain Research, 154, 192-200. [More] 
  • Paula-Barbosa, M. M., Pereira, P. A., Cadete-Leite, A. & Madeira, M. D. (2003). NGF and NT-3 exert differential effects on the expression of neuropeptides in the suprachiasmatic nucleus of rats withdrawn from ethanol treatment. Brain Research, 983(1-2), 64-73. [More] 
  • Cadete-Leite, A., Pereira, P. A., Madeira, M. D. & Paula-Barbosa, M. M. (2003). Nerve growth factor prevents cell death and induces hypertrophy of basal forebrain cholinergic neurons in rats withdrawn from prolonged ethanol intake. Neuroscience, 119(4), 1055-1069. [More] 
  • Ferreira, S. M., Paula-Barbosa, M. M. & Madeira, M. D. (2002). Prolonged alcohol intake leads to reversible depression of corticotropin-releasing hormone and vasopressin immunoreactivity and mRNA levels in the parvocellular neurons of the paraventricular nucleus.. Brain Research, 954(1), 82-93. [More] 
  • Ferreira, S. M., Madeira, M. D., Ruela, C. & Paula-Barbosa, M. M. (2002). Prolonged alcohol intake leads to irreversible loss of vasopressin and oxytocin neurons in the paraventricular nucleus of the hypothalamus. Brain Research, 925(1), 76-88. [More] 
  • Madeira, M. D., Ferreira-Silva, L., Ruela, C. & Paula-Barbosa, M. M. (2001). Differential effects of the aging process on the morphology of the hypothalamic ventromedial nucleus of male and female rats.. Neuroscience Letters, 314(1-2), 73-76. [More] 
  • Madeira, M. D., Silva, L. F. & Paula-Barbosa, M. M. (2001). Influence of sex and estrus cycle on the sexual dimorphisms of the hypothalamic ventromedial nucleus: stereological and Golgi study.. Journal of Comparative Neurology, 432(3), 329-345. [More] 
  • Paula-Barbosa, M. M., Ferreira, S. M., Andrade, J. P., Cadete-Leite, A. & Madeira, M. D. (2001). Nerve growth factor restores mRNA levels and the expression of neuropeptides in the suprachiasmatic nucleus of rats submitted to chronic ethanol treatment and withdrawal.. Journal of Neurocytology, 30(3), 195-207. [More] 
  • Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (2000). Sexual dimorphism in the subiculum of the rat hippocampal formation. Brain Research, 875(1-2), 125-137. [More] 
  • Sá, M. J., Madeira, M. D., Ruela, C., Volk, B., Mota Miranda, A., Lecour, H. et al. (2000). AIDS does not alter the total number of neurons in the hippocampal formation but induces cell atrophy: a stereological study. Acta Neuropathologica, 99(6), 643-653. [More] 
  • Sousa, N., Lukoyanov, N., Madeira, M. D., Almeida, F. X. & Paula-Barbosa, M. M. (2000). Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience, 97(2), 253-266. [More] 
  • Madeira, M. D., Andrade, J. P. & Paula-Barbosa, M. M. (2000). Hypertrophy of the ageing rat medial preoptic nucleus. Journal of Neurocytology, 29(3), 173-197. [More] 
  • Lukoyanov, N., Brandão, F., Cadete-Leite, A., Madeira, M. D. & Paula-Barbosa, M. M. (2000). Synaptic reorganization in the hippocampal formation of alcohol-fed rats may compensate for functional deficits related to neuronal loss. Alcohol, 20(2), 139-148. [More] 
  • Sousa, N., Madeira, M. D. & Paula-Barbosa, M. M. (1999). Corticosterone replacement restores normal morphological features to the hippocampal dendrites, axons and synapses of adrenalectomized rats. Journal of Neurocytology, 28(7), 541-558. [More] 
  • Lukoyanov, N., Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1999). Effects of age and sex on the water maze performance and hippocampal cholinergic fibers in rats. Neuroscience Letters, 269(3), 141-144. [More] 
  • Lukoyanov, N., Madeira, M. D. & Paula-Barbosa, M. M. (1999). Behavioral and Neuroanatomical Consequences of Chronic Ethanol Intake and Withdrawal. Physiology & Behavior, 66(2), 337-346. [More] 
  • Madeira, M. D., Leal, S. & Paula-Barbosa, M. M. (1999). Stereological evaluation and Golgi study of the sexual dimorphisms in the volume, cell numbers, and cell size in the medial preoptic nucleus of the rat. Journal of Neurocytology, 28(2), 131-148. [More] 
  • Madeira, M. D. & Paula-Barbosa, M. M. (1999). Effects of alcohol on the synthesis and expression of hypothalamic peptides. Brain Research Bulletin, 48(1), 3-22. [More] 
  • Sá, M. J., Pereira, A., Paula-Barbosa, M. M. & Madeira, M. D. (1999). Anatomical asymmetries in the human hippocampal formation. Acta stereologica, 18(2), 161-176. [More] 
  • Sousa, N., Madeira, M. D. & Paula-Barbosa, M. M. (1998). Effects of corticosterone treatment and rehabilitation on the hippocampal formation of neonatal and adult rats. An unbiased stereological study. Brain Research, 794(2), 199-210. [More] 
  • Sousa, N., Almeida, O. F., Holsboer, F., Paula-Barbosa, M. M. & Madeira, M. D. (1998). Maintenance of hippocampal cell numbers in young and aged rats submitted to chronic unpredictable stress. Comparison with the effects of corticosterone treatment. Stress, 2(4), 237-249. [More] 
  • Leal, S., Andrade, J. P., Paula-Barbosa, M. M. & Madeira, M. D. (1998). Arcuate nucleus of the hypothalamus: Effects of age and sex. The Journal of Comparative Neurology, 401, 65-88. [More] 
  • Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1998). Differential vulnerability of the subiculum and entorhinal cortex of the adult rat to prolonged protein deprivation. Hippocampus, 8(1), 33-47. [More] 
  • Sousa, N., Madeira, M. D. & Paula-Barbosa, M. M. (1997). Structural alterations of the hippocampal formation of adrenalectomizd rats: an unbiased stereological study. Journal of Neurocytology, 26(6), 423-438. [More] 
  • Madeira, M. D., Andrade, J. P., Lieberman, A. R., Paula-Barbosa, M. M., Sousa, N. & Almeida, O. F. (1997). Chronic Alcohol Consumption and Withdrawal Do Not Induce Cell Death in the Suprachiasmatic Nucleus, But Lead to Irreversible Depression of Peptide Immunoreactivity and mRNA Levels. The Journal of Neuroscience, 17(4), 1302-1319. [More] 
  • Andrade, J. P., Castanheira-Vale, A. J. & Madeira, M. D. (1996). Time scale and extent of neuronal and synaptic loss in the hippocampal formation of malnourished adult rats. Brain Research, 718(1-2), 1-12. [More] 
  • Madeira, M. D., Sousa, N. & Paula-Barbosa, M. M. (1996). Effects of high and low levels of glucocorticoids on the morphology of the hippocampal formation: A stereological study. Morphometry and its Applications in Medical Sciences, 227-240. [More] 
  • Brandão, F., Cadete-Leite, A., Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1996). Piracetam promotes mossy fiber synaptic reorganization in rats withdrawn from alcohol. Alcohol, 13(3), 239-249. [More] 
  • Andrade, J. P., Castanheira-Vale, A. J., Paz-Dias, P. G., Madeira, M. D. & Paula-Barbosa, M. M. (1996). The dendritic trees of the neurons from the hippocampal formation of adult protein-deprived rats. A quantitative Golgi study. Experimental Brain Research, 109, 419-433. [More] 
  • Madeira, M. D., Sousa, N., Santer, R. M., Paula-Barbosa, M. M. & Gundersen, H. (1995). Age and sex do not affect the volume, cell numbers, or cell size of the suprachiasmatic nucleus of the rat: an unbiased stereological study.. Journal of Comparative Neurology, 361(4), 585-601. [More] 
  • Sá, M. J., Madeira, M. D., Cruz, C. & Paula-Barbosa, M. M. (1995). Morphometric study of the frontal cortex in subacute sclerosing panencephalitis. Acta Neurologica Scandinavica, 92(3), 225-230. [More] 
  • Sousa, N., Madeira, M. D., Ruela, C. & Paula-Barbosa, M. M. (1995). Structural reorganization in the supraoptic nucleus of withdrawn rats following long-term alcohol consumption. Alcoholism: Clinical and Experimental Research, 19(4), 879-885. [More] 
  • Madeira, M. D. & Lieberman, A. R. (1995). Sexual dimorphism in the mammalian limbic system. Progress in Neurobiology, 45(4), 275-313. [More] 
  • Madeira, M. D. & Andrade, J. P. (1995). Stereological analysis of the hippocampal formation of male and female hypothyroid rats. Behavioural Brain Research in Naturalistic and Semi-Naturalistic Settings, 82(3), 343-351. [More] 
  • Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1995). Evidence of reorganization in the hippocampal mossy fiber synapses of adult rats rehabilitated after prolonged undernutrition. Experimental Brain Research, 104, 249-261. [More] 
  • Andrade, J. P., Madeira, M. D. & Paula-Barbosa, M. M. (1995). Effects of long-term malnutrition and rehabilitation on the hippocampal formation of the adult rat. Journal of Anatomy, 187, 379-393. [More] 
  • Sousa, N., Madeira, M. D., Paula-Barbosa, M. M. & Bujis, R. (1994). The vasopressinergic innervation of the lateral septum of the rat after chronic alcohol consumption and withdrawal. Brain Research, 648(1), 53-58. [More] 
  • Ruela, C., Sousa, N., Madeira, M. D. & Paula-Barbosa, M. M. (1994). Stereological study of the ultrastructural changes induced by chronic alcohol consumption and dehydration in the supraoptic nucleus of the rat hypothalamus. Journal of Neurocytology, 23, 410-421. [More] 

Projects

Contactos
Centro de Morfologia Experimental
Faculdade de Medicina da Universidade do Porto
Al. Professor Hernâni Monteiro
4200-319 Porto
tel. (+351) 22 551 36 16
fax (+351) 22 551 36 17
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© 2017 Departamento de Anatomia / Produção CI FMUP